The Longitudinal Clinical and Genetic Study of Parkinson's Disease (LONG-PD Study)
Aims: The clinical and genetic factors that influence motor and non-motor severity, progression and outcomes in Parkinson’s disease are unknown. Identification of these factors may allow us to individualize the care of patients and improve neurological health. The Genetic Epidemiology of Parkinson’s Disease (GEO- PD) consortium clinics care for thousands of patients each year. The purpose of this study is to develop a Web-based platform for the capture and sharing of standardized data that measure motor and non-motor severity, progression and outcomes in Parkinson’s disease across 25 global sites—from 18 countries, 5 continents, 4200 cases. These patients will be followed for 15 years for collaborative research studies. Additionally, DNA will be shared in a central repository to conduct genomic studies of severity, progression and outcomes in Parkinson's disease.
Principal Investigator: Aikaterini Markopoulou, MD, PhD
NorthShore Project Number: EH15-283
Funding Source: NorthShore University HealthSystem
Contact: Call 847.503.4335 with questions regarding the study
Open to enrollment: Yes
Genetic Analysis of Familial Parkinsonism
Aim: The purpose of this study is to identify inherited factors that may cause Parkinson’s disease or Parkinsonism.
Principal Investigator: Aikaterini Markopoulou, MD, PhD
NorthShore Project Number: EH16-166
Contact: Call 847.503.4335 with questions regarding the study
Open to enrollment: Yes
The Role of Genetics and Neurophysiology in the Outcomes of Deep Brain Stimulation Surgery
Aims: This retrospective data analysis study aims to assess the contribution of baseline clinical and genetic characteristics to clinical outcomes; to identify, in Parkinson’s disease patients who have undergone subthalamic nucleus deep brain stimulation (STN-DBS), patterns of local field potential (LFPs) activity from the subthalamic nucleus (STN) and correlate them with treatment response over serial clinical assessments; and to evaluate associations of patterns of STN LFP activity with clinical outcomes, genetic status, and family history.
Principal Investigator: Katerina Markopoulou, MD, PhD
NorthShore Project Number: EH23-190
Contact: Please call 847.503.4335 with questions regarding the study
Open to Enrollment: Yes